Medical Laboratory Scientist I - Cancer Center

General Summary:

Medical Technologist at the MGH Cancer Center in the Immune Monitoring Laboratory. We are looking for a highly motivated individual to support the development of this service-orientated, clinically focused research laboratory. The mission of the laboratory is to provide comprehensive high quality immune monitoring that is innovative and enables translational research of immune-based therapies. We work closely with the Maus Lab, and therefore have a unique opportunity to work on groundbreaking CAR-T clinical trials in additional to studies using FDA approved products. Current trials include the study of the immune response in patients following infusion with CAR-T for treatment of glioblastoma, multiple myeloma and lymphoma.

Principal Duties and Responsibilities:

• Process and bank blood, bone marrow, CSF and solid tissues from patients undergoing immune-based therapy.
• Perform multi-color flow cytometry using a 12 color BD FACS Lyric and the spectral Aurora. Perform flow data analysis to monitor CAR T expansion and function.
• Use Dynex DS2 for ELISA automation in addition to quantification of cytokine, soluble receptors and antibodies in serum, plasma and CSF using Luminex and ELLA multiplex platforms.
• Use QIAcube to perform extraction of DNA and RNA from patient samples.
• Use QIAgility and Bio-Rad automation to perform ddPCR for monitoring CAR-T expansion.
• Perform cell sorting using the SONY MA900.
• Support the introduction of new equipment into the laboratory workflow, including validation and verification.
• Train new lab members in the various techniques.
• Perform preventative maintenance and calibration of specialized equipment.
• Contribute to assay development, quality control processes, and technical validation.
• Maintain accurate sample storage and record keeping.
• Contribute to writing method validations, SOPs following document control procedures.
• Contribute to incident investigations.
• Attend and contribute to weekly lab meetings.
• Attend meetings with trial sponsors and clinical teams and contribute to data presentations.

Qualifications:

B.S. Degree is required. Minimum 2 years of laboratory experience is required and ASCP certification is preferred. Experience working in a CLIA/CAP regulated laboratory would be desirable.

Skills & Competencies Required:

• Experience working with human samples.
• Meticulous and methodical record keeping.
• Ability to pick up techniques quickly.
• Experience working with LIMS systems.
• Experience in assay development and validation.
• Experience with either flow cytometry or molecular diagnostics would be advantageous.
• Knowledge of hematological malignancies would be an advantage.
• Excellent written communication skills and competency in writing SOPs.
• Must be organized and capable of following protocols.
• Good hand and eye coordination and manual dexterity.
• Ability to work well with others.
• Must have demonstrable experience in method development and/or trouble shooting.
• Must be proficient with MS Office programs such as MS Word, PowerPoint, Excel and statistical packages.
• Ability to work independently on designated projects.

Massachusetts General Hospital is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.