Postdoctoral Scholar
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![]() United States, Illinois, Chicago | |
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Apply for Job Job ID
51819Location
Chicago, IllinoisAdd to Favorite Jobs Email this Job Department: MED-Cell&DevelopmentalBiology Job Summary The Ozbudak Lab is looking for a postdoctoral fellow interested in combining multidisciplinary approaches to discover biophysical mechanisms governing spatiotemporal pattern formation during embryonic development. Embryos develop spatiotemporal patterns by encoding and interpreting biological signals in real time. Despite unavoidable fluctuations in gene expression and cell signaling, embryonic development is robust and reproducible. A striking example of robust spatiotemporal patterning is the rhythmic segmentation of somites, which are precursors of the vertebral column. Segmentation of somites is controlled by: 1) oscillatory expression of the vertebrate segmentation clock genes, 2) short-distance Notch signaling, 3) long-distance Fg and Wnt signaling gradients, 4) a network of transcription factors integrating outputs of the segmentation clock and the signaling pathways, and 5) cytoskeletal and biomechanical processes executing physical formation of segment boundaries. Errors in this regulatory cascade result in various birth defects, including congenital scoliosis. We combine single-cell microscopy measurements, time-resolved perturbation experiments, biophysical modeling, and computational simulations to decipher the mechanism underlying robust spatiotemporal pattern formation and cell fate determination. Relevant publications: Nature 2021 589:431-436; Nature 2023 613:153-159. Dev Cell 2024. We are looking for a colleague who is highly motivated and independent. Please send a cover letter detailing your past research accomplishments and future research goals, and your CV by email to: ozbudak@northwestern.edu Specific Responsibilities:
Minimum Qualifications: (Education, experience, and any other certifications or clearances) For this section, only list the minimum requirements needed to perform the work, and leave the 'desired or nice to have' qualifications for the 'Preferred Qualifications' section. The education, work experience, skills, abilities, licenses/certifications should all directly relate to the job's responsibilities.
Benefits: Work-Life and Wellness: Professional Growth & Development: Northwestern University is an Equal Opportunity Employer and does not discriminate on the basis of protected characteristics, including disability and veteran status. View Northwestern's non-discrimination statement. Job applicants who wish to request an accommodation in the application or hiring process should contact the Office of Civil Rights and Title IX Compliance. View additional information on the accommodations process. |