Research Associate II - Tumor Immunology

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The laboratory of Dr. Kelly Mahuron is in search of a talented Research Associate II (RA II).

We are a basic and translational immunology laboratory that studies how the immune system can be harnessed to fight cancer. Specifically, our research focuses on tumor-infiltrating lymphocytes (TILs), an immune cell critical for eliciting an anti-tumor response. We seek to understand which immune cell populations are required for a robust response to immunotherapy, and to develop novel immuno-oncology therapies such as adoptive cell therapy and oncolytic viruses.

Under general supervision of the Principal Investigator, or designee, the RA II directs the work of a laboratory or undertakes research projects in collaboration with academic supervisor, making innovative contributions pertaining to laboratory procedures which may not change the course of an investigation but do indicate significant independent contribution beyond the RA I level.

As a successful candidate, you will:

• Engage in hands-on laboratory research with opportunities for translational work with clinical studies, and the skill sets that will be acquired include mouse work, flow cytometry and cell sorting, single-cell RNA and TCR sequencing, in vitro functional assays, bioinformatics, and genetic engineering.
• Perform a variety of routine and non-routine laboratory research experiments. Record and validate results for accuracy and completeness.
• Troubleshoot procedures if experiment results are unexpected or unsatisfactory. Recommend alternative procedures.
• Accurately record work performed including results and methodology. Calculate, compile, and analyze data obtained from work performed.
• Independently evaluate research data and initiate alternative approaches to improve the quality of results by providing input to overall research design. Train lab staff in specialized procedures, equipment, and theoretical concepts behind unique tests.
• May contribute to the preparation of manuscripts by describing methods and specialized techniques. Keep abreast of new and improved techniques.
• Ensure that all laboratory activities are carried out in compliance with each procedure(s) by utilizing safety procedures and guidelines in handling, storage and disposal of bio-hazardous, infectious and toxic material.

Your qualifications should include:

• Bachelor's degree. Master's degree preferred.
• Two years related research/ laboratory experience with a Bachelor's degree or one year related research/ laboratory experience with a Master's degree.

Preferred qualifications:

• Experience with mouse work, flow cytometry and cell sorting, single-cell RNA and TCR sequencing, in vitro functional assays, bioinformatics, and genetic engineering.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity, and inclusion, please click here.

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