New 
Senior Scientist
 Spectraforce Technologies | |
 United States, California, South San Francisco | |
 Mar 12, 2025 | |
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Title - Senior Scientist Duration - 12 months Location - South San Francisco, CA 94080 Note: Onsite, 100% lab-based role. Possibility of extension. Qualifications: This is a Bio-conjugation Scientist role, so please advertise it as per this title to get the relevant resumes and candidates' applications. * Minimum qualifications include a B.S./M.S/ PHD in chemistry, biochemistry, or related field, with industrial or academic experience. Experience and Skills Required: * Hands-on experience with conjugation, purification, and characterization of antibody-drug conjugates and experience using analytical techniques/instrumentation, including chromatographic techniques such as HIC (Hydrophobic Interaction Chromatography) and RP (Reverse Phase), SEC, SDS-PAGE, UV?Vis. * Nice to have skills: Biologics analytic experience and purification techniques. * Must have: Bio-conjugation experience, protein biochemistry and Chemistry background. * Personality: Team player, adheres to timeline, Communicative and collaborative. Responsibilities: This is a Bio-conjugation Scientist role with MRL SSF Discovery Chemistry group. Merck is currently seeking a highly motivated and exceptional Bio-conjugation Scientist for a position within the Discovery Chemistry Department located at our South San Francisco, CA site. * The successful candidate will join multidisciplinary, highly collaborative discovery teams to invent novel medicines by applying optimized conjugation protocols, analytical techniques, and data analysis to synthesize drug candidates and intermediates. * Successful candidates must have excellent interpersonal, collaboration, and communication skills in a team environment. * Additionally, it is expected that the successful candidate will learn quickly through on-the-job training to become increasingly skilled and independent in reaction setup, route design and optimization. Specific responsibilities will include: * Perform bioconjugations of linker-payload combinations to antibodies with emphasis on in-house established methods * Selection and application of appropriate purification techniques for biologics (i.e., SEC, hydrophobic interaction chromatography, ion exchange chromatography) * Acquisition and interpretation of analytical data such as LC/MS. | |