Scientist, Biology

The Research team is looking for a Scientist who will be an active participant in a vibrant, multidisciplinary drug discovery team and will use novel, innovative tools and technologies for investigating genetically validated targets amenable to targeting using RNAi Therapeutics.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

* Conduct investigative research on RNAi therapeutics in the CNS as well as extrahepatic space, evaluating siRNA delivery to various cell lines in vitro, including both immortalized and induced pluripotent stem cell (iPSC) lines.
* Develop and execute assays to characterize the uptake kinetics and pharmacodynamics of conjugated siRNAs using molecular, biochemical, and high-content fluorescent microscopy techniques.
* Design, lead, and perform in vivo rodent studies to assess the pharmacodynamics and pharmacokinetics of extrahepatic targeting siRNA.
* Continuously learn and apply new techniques to support both in vitro and in vivo studies related to pipeline targets and siRNA platform advancements.
* Maintain accurate data records, conduct thorough data analysis, and prepare well-documented experimental reports in a timely manner.
* Effectively communicate research findings and updates to key stakeholders across the organization.
* Responsible for data entry, data analysis in a timely manner, and preparation of clearly articulated experimental reports.

Qualifications

* Proficiency in mammalian cell culture, including maintenance, transfection, and stable selection, as well as molecular biology techniques for RNA/DNA/protein quantification (qPCR, Western blotting, ELISA, immunoprecipitations).
* Experience in rodent handling, dosing (SubQ/IV), and blood/tissue collection and necropsy.
* Experience with human iPSC culture and differentiation.
* Prior experience conducting and interpreting in vivo rodent studies.
* Strong laboratory skills with the ability to work independently.
* Excellent written and verbal communication skills, along with strong interpersonal abilities.

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.