Postdoctoral Research Scholar- Piedrahita Lab

Dr. Piedrahita's laboratory is primarily interested in the behavior of stem and progenitor cells in vitro and in vivo, and the development of large animal models of use in human and veterinary regenerative medicine. Towards this end, his research combines techniques in functional genomics, stem cells, cell biology, embryo manipulation, and molecular biology. The primary purpose of this position is to assist in analyzing a new gene edited pig to study the role of LGR5 cells in multiple organs in particular the lung. Both during development and their involvement in diseases such as IPF, COPD and asthma. The candidate should have a strong background in cell biology, organoid biology, molecular biology and be interested in lung physiology/biology.

Duties and Responsibilities
Assist and lead projects related to the continued improvement of the LGR5 pig model. Lead the analysis of LGR5 stem cells and help elucidate their role in lung development and in repair after injury. Assist in the analysis of single cell RNAseq data to understand the developmental origin of lung LGR5 cells. Utilize organoid and indued pluripotent stem ( IPS) cells models to unravel the function of LGR5 cells in the lung. Participate on other laboratory projects as needed.

Additional Duties

Participate in mentoring of other graduate and undergraduate students.

Cell biology, molecular biology, cell culture.

Organoid biology, stem cell biology including generation of IPS cell lines, lung physiology, gene expression analysis (RNAseq and scRNA seq).

Ability or interest in working with swine as a model system.

N/A

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