Postdoctoral Fellow - CAR T Cancer Research

Join the forefront of groundbreaking research at theBeckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

TheChintan ParekhLab is seeking a Postdoctoral Fellow to work on research projects focused on defining mechanisms underlying interactions between CAR T-cells and the bone marrow microenvironment. This project will usespectral flow cytometry,in vitroand in vivo CAR T-cell assays and gene knockdown, overexpression, and CRISPR knockoutstudies.

The lab focuses on mechanisms underlying human T-cell development and lymphoid leukemogenesis and the application of these mechanistic insights to the development of novel anti-cancer immunotherapy approaches, methods to improve T-cell recovery following bone marrow transplantation, and anti-leukemia therapies. They investigate cellular and molecular mechanisms via a combination of computational biology and functional in vitro and in vivo studies of human normal blood progenitor cells, immune cells, and leukemia cells.The lab delineates complex layers of biological regulation by integrating data from a wide range of studies, includingtranscriptomic, epigenomic, proteomic, T-cell receptor rearrangement sequencing, high dimensional spectral flow cytometry, in vitro organoid, and in vivo xenotransplantation assays.The Parekh labis funded by R01 grants from the National Institute of Health and has publications in high impact journals like Nature Immunology and Immunity.

To learn more about Dr. Chintan Parekh please visit here.

As a successful candidate you will:

* Design and conduct of experiments related to current projects

* Analyze primary data

* Prepare manuscripts and other research presentations.

Your qualifications should include:

* PhD or M.D. in Immunology, Cancer Biology or related field

* Experience in flow cytometry is preferred

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

To learn more about our Comprehensive Benefits, pleaseCLICK HERE.