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HR Operations & Payroll Analyst

BioCryst Pharmaceuticals
United States, North Carolina, Durham
4505 Emperor Boulevard (Show on map)
Jan 24, 2026

COMPANY:

At BioCryst, we share a deep commitment to improving the lives of people living with complement-mediated and other rare diseases. For over three decades we've been guided by our passion for not settling for "ordinary" in our quest to develop novel medicines. We leverage our expertise in structure-guided drug design to develop first-in-class or best-in-class oral small-molecule and protein therapeutics, led by the efforts of our team of expert scientists in our Discovery Center of Excellence in Birmingham, Alabama. Our global headquarters is in Durham, North Carolina and our employees span the globe across sites in multiple countries. We are proud of our culture of engagement and accountability that rewards people for innovative thinking and achievement of key objectives. For more information, please visit our website at www.biocryst.com or follow uson LinkedIn and Instagram.

JOB SUMMARY:

The HR Operations & Payroll Analyst plays a central role in ensuring a seamless, accurate, and positive owner experience across the full lifecycle, from onboarding through payroll execution. This role combines hands on HR operational support with responsibility for global payroll processing, compliance, and data integrity. This position partners closely with HR, Finance, and cross functional teams to deliver high quality service in a fast paced and dynamic environment, helping BioCryst continue to make hope a reality for patients suffering from rare and orphan diseases.

ESSENTIAL DUTIES & RESPONSIBILITIES:

HR Operational responsibilities will include:

  • Oversee and execute Onboarding Program for all new owners
  • Process a high volume of transactions (hires, personnel changes, reclassifications, terminations) with accuracy and timeliness
  • Support the HR team in various HR initiatives and projects, including talent acquisition, HR systems, compensation, and benefits.
  • Research and resolve open owner questions submitted to the HR team
  • Ensure data accuracy and integrity in HR systems.
  • Assist in maintaining the Owner Handbook through annual updates and changes

Payroll responsibilities will include:

  • Assist with the global payroll delivery by coordinating with internal partners and external payroll providers
  • Promote data integrity by performing audits and collaborating with business partners in resolving discrepancies
  • Ensure cross-training in all processes by collaborating with team members and developing work instructions
  • Research and respond to payroll-related inquiries from owners and business partners
  • Review and process payroll for equity transactions including ESPP, stock option exercises, and restricted stock unit (RSU) vesting
  • Other duties as assigned

EXPERIENCE & QUALIFICATIONS:

  • Bachelor's Degree, or an equivalent combination of education and experience.
  • Preferred 2 years of experience supporting HR and/or payroll teams
  • Demonstrated ability to be an inquisitive, self-starting problem solver who digs in to understand root causes and follows tasks through to resolution
  • Previous experience with fast-paced environments, where priorities shift and change
  • Solid understanding of Microsoft Office Suite Products - Outlook, Word, Excel, PowerPoint, etc.
  • Strong organizational skills, keen attention to detail, and ability to prioritize projects and meet highly aggressive deadlines
  • A cheerful, team-oriented, adaptable, and can-do attitude
  • Outstanding interpersonal and communication skills

The statements in this position description are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of responsibilities, duties, and skills required of personnel so classified. The manager may assign additional responsibilities and assignments from time to time.

BioCryst is an equal opportunity employer and is committed to providing equal employment opportunities without regard to age, race, religion, sex, sexual orientation, gender identity, national origin, Veterans status, disability and/or other protected class characteristics. Additionally, BioCryst is committed to achieving its business objectives in compliance with all federal, state and local law.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.

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