Associate Scientist - Cellular Model
 The Jackson Laboratory | |
 United States, Connecticut, Farmington | |
| 10 Discovery Drive (Show on map) | |
 Feb 13, 2026 | |
|
The Associate Scientist will serve as the platform lead for functional cellular assays and high-content screening projects at the Single Cell Biology Laboratory (SCBL) within The Jackson Laboratory for Genomic Medicine, ensuring the timely delivery of high-quality, robust data. The SCBL is a core facility supporting the scientific research community with cutting-edge single-cell technologies, including dissociative single-cell omics, spatial omics, and high-content screening. This role is central to the lab's functional biology and screening capabilities, requiring deep expertise in advanced cell culture systems, strong project coordination, and effective communication with scientific stakeholders.
The ideal candidate will be the technical expert for functional cellular workflows, from experimental design and culture optimization to assay execution, data quality control, and workflow development. You will leverage your strong background in cell biology and advanced culture systems to support and expand capabilities in 2D and 3D cell culture, organoids, co-culture assays, and iPSC-based models. Experience with live-cell imaging, high-content or high-throughput screening, and laboratory automation or liquid handling systems is strongly preferred.
In this role, you will work closely with internal and external investigators to design and execute complex experiments, maintain high-quality standards across projects, and contribute to the development of innovative functional assays within the SCBL.
Knowledge, Skills, and Abilities Required:
Required Education:
PhD in Biology, Molecular Biology, or a related scientific field.
Experience: 2-4 years of experience in a core facility, industry setting
or min of 4 years in research lab. Molecular & RNA Biology: Deep and comprehensive understanding of RNA and molecular biology principles, including associated assays.
Cellular Models Experience: 2D and 3D mammalian cell culture expertise, iPSCs/progenitor cell differentiation and extended characterization, primary cell line derivation (2D and organoids)
HCS/HTS: First hand experience on high throughput (96-, 384- or 1536-well plate format) cell assays for drug screens, differentiation and perturbations assays, live imaging and biochemical analysis (IC50, GR50,...)
Liquid Handling and Automation: familiar with liquid handling and automation instruments used for HCS/HTS screens
Sample Handling: Direct experience with tissue processing, sectioning, handling, and profiling using immunohistochemistry (IHC) techniques.
Documentation: Experience in writing Standard Operating Procedures (SOPs) and familiarity with Laboratory Information Management Systems (LIMS) and Electronic Lab Notebooks (ELN).
Operational Skills: Proven project and lab management experience, including managing stock, inventory, and instrument uptime.
Soft Skills: Exceptional communication, interpersonal, and presentation skills; proven ability to thrive as a team player within interdisciplinary groups.
Preferred:
Education: Ph.D. preferred
Technical Breadth: Comprehensive knowledge of various spatial genomics technologies (e.g., Xenium, Visium, MERFISH, seqFISH).
Single-Cell Experience: Hands-on experience with single-cell technologies (e.g., 10x Chromium, smart-seq, split-and-pool methods).
Imaging-Based Spatial Genomics Expertise: Hands-on experience with FISH-based platforms, including 10x Genomics Xenium, MERFISH, and seqFISH.
Biopharma Industry Experience: Preferred experience working in an industrial setting, such as the biotechnology or pharmaceutical sector, demonstrating familiarity with industry-standard workflows and requirements.
Histology Expertise: Experience in histopathology and tissue/mircotissue processing.
Development: Proven track record in technology development or assay optimization.
Pay Range: $69,711 -
$90,624, salary determined by experience About JAX: The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California),Japan andChina. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visitwww.jax.org. EEO Statement: The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws. | |