Associate Research Scientist

The Columbia Center for Translational Immunology (CCTI) is seeking an Associate Research Scientist (ARS) to lead cell engineering projects on antigen-specific tolerance and therapy for autoimmune diabetes in the Creusot lab.

This role is primarily related to ongoing and planned studies for the next two years on the use of engineered hematopoietic stem and progenitor cells and fibroblastic reticular cells as agents to specifically reprogram autoreactive T cells in vivo. The responsibilities will include performing lentiviral and CRISPR-based cell engineering, injecting/implanting cells, tissues and/or bioscaffolds, monitoring cell/tissue engraftment and antigen-specific T cells in lymphoid tissues and pancreas, and mechanistically assessing the fate of antigen-specific T cells. The ARS will also assist with other projects involving mouse surgeries and transplantation of human tissues, as well as with the maintenance of cell lines and mouse strains needed for these projects.

The ARS is expected to be working independently while collaborating with other team members, and to also provide training and supervision to students in the lab. The research will take place in the Creusot lab. The ARS will be assigned to a designated bench and desktop station, and will have access to state-of-the-art equipment and core facilities at the CCTI and on campus.

The time allocation for this position includes seventy percent for experimental work, twenty percent for data analysis and presentation, and ten percent for mentoring and other academic tasks. The ARS will report directly to Dr. Creusot. In the case of collaborative projects with other investigators, the ARS will stay in the Creusot Lab under the PI's supervision.

Minimum Qualifications:

MD or PhD degree in Immunology, or a similar research field

Preferred Qualifications:

The candidate ideally will have five years of experience with advanced cellular and immunological assays, flow cytometry, in vivo mouse experiments and surgeries, lentiviral transduction, immune and stromal cell isolation and culture. Familiarity with cell engineering techniques and T1D immunology preferred.

Columbia University is an Equal Opportunity Employer / Disability / Veteran

Pay Transparency Disclosure

The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.