Postdoctoral Scholar - Neural and Behavioral Sciences

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JOB DESCRIPTION AND POSITION REQUIREMENTS:

The Shilpi Paul and Anirban Paul labs in the Department of Neural and Behavioral Sciences at Penn State University College of Medicine in Hershey, PA, is looking for a highly motivated postdoctoral scholar at all levels.

The work in the laboratory of Dr. Shilpi Paul is focused on understanding how cells exposed to endogenous or exogenous stressors utilize damage response pathways to maintain genome and proteome integrity; how misregulation of these pathways cause cancer and/or chemotherapy resistance, aging and neurological disorders. Dr. Anirban Paul's interest are in understanding brain function at the level of cell types in the context of development and aging.

Both the labs are collaborating on multiple projects:

1. Investigating the role of Tranlesion synthesis polymerases in aging and Alzheimer's using mice models.

2. Impact of postnatal exposure to xenoestrogens on neuronal developmental trajectories.

3. Using MERSCOPE a high multiplexing, high resolution in situ platform investigating the spatial transcriptomics at single-cell level of DNA damage response pathways in:

(i) Alzheimer's mice models, normal aging and after postnatal exposure to xenoestrogens

(ii) Initiation and progression of breast cancer due to chronic exposure to estrogen metabolites using organoid system.

Both the labs have multiple internal and external collaborative projects ongoing.

Successful postdoctoral scholars would require experience and skills that would include mammalian cell culture techniques, establishing cancer chemotherapy resistance cell lines, develop siRNA and chemotherapy drug delivery systems in cancer cell lines and in vivo mice models, molecular and cell biology techniques, cellular assay development, biochemistry and mice handling. Candidates are expected to be responsible for writing drafts for publications and training graduate students and technical lab staff.

Candidate will be working with a diverse and vibrant collaborative research team comprised of quantitative biologists, biochemists, neuroanatomists, imaging experts, oncologists and geneticists.

Required qualifications:

PhD or equivalent degree in biology, biochemistry, molecular cell biology, bio-medical sciences, or any related discipline at time of hire. Proficiency in English is required.

To Apply:

Please complete your online application and attach the following support documentation as separate attachments. Updated CV, brief cover letter indicating prior research experience and career goals and 2-3 relevant publications in addition to the names of 2 references.

This is a limited term position for one year from hire date with possibility of refunding.

Employment will require successful completion of background check(s) in accordance withUniversitypolices.

The Pennsylvania State University is committed to and accountable for advancing diversity, equity, and inclusion inall ofits forms.We embrace individual uniqueness, foster a culture of inclusive excellence that supports both broad and specific diversity initiatives, leverage the educational and institutional benefits of diversity, and engage all individuals to help them thrive. We value inclusive excellence as a core strength and an essential element of our public service mission.

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