Postdoctoral Fellow - Cellular Gene Therapy and Stem Cell Research

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

Dr. Angelo Cardoso is looking for a talented and highly motivated Postdoctoral Fellow to join the Laboratory for Cellular Medicine, Center for Gene Therapy. You will join a well-established group performing cutting-edge research, development and qualification of large-scale processes, and manufacture of products for gene therapy clinical trials, including first-in-human studies with genetically engineered hematopoietic stem and progenitor cells (HSPC) and T cells.

As a successful candidate, you will:

* Conduct research on next-generation targeted gene modification of human HSPC and iPSC, on strategies to modulate stemness and on the development of niche-mimetics.

* Interact with the Process Development team and will participate in the optimization of methods for efficient gene-modification of target cells and their transfer into clinical-scale manufacture processes, as well as in the development and qualification of project-specific potency and identity assays for release and characterization of these therapeutic products.

* You will be expected to perform high quality original research work, participate in the clinical translation of their work, prepare manuscripts for publication, contribute to extramural grant applications and the preparation of progress reports for funding agencies, and to submitrelevantpostdoctoralfellowship applications.

* PhD or MD in biological sciences with a strong interest in translational research. Preference will be given to candidates with expertise in the study of hematopoiesis and biology of HSPC, experimentation with primary human cells and iPSC, and gene editing and viral transduction.

* Expertise in cell selection, hematopoietic functional assays, multiparametric flow cytometry, PCR, and basic knowledge of molecular biology, are required.

* Excellent communication skills.

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